Identification of physicochemical properties that modulate nanoparticle aggregation in blood

• Ludovica Soddu,
• Duong N. Trinh,
• Eimear Dunne,
• Dermot Kenny,
• Giorgia Bernardini,
• Ida Kokalari,
• Arianna Marucco,
• Marco P. Monopoli and
• Ivana Fenoglio

Beilstein J. Nanotechnol. 2020, 11, 550–567, doi:10.3762/bjnano.11.44

• –protein interaction may lead to bridging among particles, thus promoting agglomeration [23]. In the present study, a set of six silica and carbon NPs of known size and morphology was used to evaluate the effect of the size and surface properties on the protein corona composition, platelet activation and

Internalization mechanisms of cell-penetrating peptides

• Ivana Ruseska and
• Andreas Zimmer

Beilstein J. Nanotechnol. 2020, 11, 101–123, doi:10.3762/bjnano.11.10

Surface coating affects behavior of metallic nanoparticles in a biological environment

• Darija Domazet Jurašin,
• Marija Ćurlin,
• Ivona Capjak,
• Tea Crnković,
• Marija Lovrić,
• Michal Babič,
• Daniel Horák,
• Ivana Vinković Vrček and
• Srećko Gajović

Beilstein J. Nanotechnol. 2016, 7, 246–262, doi:10.3762/bjnano.7.23

• ; protein interaction; silver; surface coating; Introduction Functional nanomaterials, including nanoparticles, nanocrystals, and nanoclusters, are promising tools for new medicinal applications, particularly for clinical use in disease diagnosis and treatment [1][2]. However, only a few nanomaterials are

Protein corona – from molecular adsorption to physiological complexity

• Lennart Treuel,
• Dominic Docter,
• Michael Maskos and
• Roland H. Stauber

Beilstein J. Nanotechnol. 2015, 6, 857–873, doi:10.3762/bjnano.6.88

• time was confirmed as a critical factor, a multi parameter classifier will likely be required to model NP–protein interaction profiles in biological relevant environments [10][162]. A direct link between these findings and their (patho)biological relevance was also established in this study by in vitro

Inorganic Janus particles for biomedical applications

• Isabel Schick,
• Steffen Lorenz,
• Dominik Gehrig,
• Stefan Tenzer,
• Wiebke Storck,
• Karl Fischer,
• Dennis Strand,
• Frédéric Laquai and
• Wolfgang Tremel

Beilstein J. Nanotechnol. 2014, 5, 2346–2362, doi:10.3762/bjnano.5.244

• nanoparticles due to the underlying nanoparticles lead to significant changes in protein interaction. Conclusion Although Janus particles were established conceptually only about 20 years ago, a large body of research has been invested in this field of colloidal chemistry. In this review, we highlighted

Effects of surface functionalization on the adsorption of human serum albumin onto nanoparticles – a fluorescence correlation spectroscopy study

• Pauline Maffre,
• Stefan Brandholt,
• Karin Nienhaus,
• Li Shang,
• Wolfgang J. Parak and
• G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2014, 5, 2036–2047, doi:10.3762/bjnano.5.212

• the concentration of free protein, [P], is modeled by the Hill equation, The midpoint of the transition, that is, the concentration of protein free in solution at half coverage in equilibrium, is given by the coefficient K′D quantifying the strength of the NP–protein interaction. The Hill coefficient

• energy only corresponding to a few hydrogen bonds and, therefore, exhibit large-scale fluctuations at room temperature [56][57]. Thus, already fairly weak interactions can disturb or even unfold proteins. Depending on the details of the NP–protein interaction, a simple equilibrium binding model may in

Atomic force microscopy recognition of protein A on Staphylococcus aureus cell surfaces by labelling with IgG–Au conjugates

• Elena B. Tatlybaeva,
• Hike N. Nikiyan,
• Alexey S. Vasilchenko and
• Dmitri G. Deryabin

Beilstein J. Nanotechnol. 2013, 4, 743–749, doi:10.3762/bjnano.4.84

• on the surface of B. licheniformis [18], which suggests their inability of protein–protein interaction through the Fc region. The result of co-incubation of S. aureus and B. licheniformis after the interaction with IgG–Au is shown in Figure 3b. After treatment with the conjugates, these bacterial

New hybrid materials based on poly(ethyleneoxide)-grafted polysilazane by hydrosilylation and their anti-fouling activities

• Thi Dieu Hang Nguyen,
• François-Xavier Perrin and
• Dinh Lam Nguyen

Beilstein J. Nanotechnol. 2013, 4, 671–677, doi:10.3762/bjnano.4.75

• Si–H/allyl ratio (see Table 1). The higher PEO grafting density of PSZ-PEO350 could explain its higher anti-fouling activity. These results are also in accordance with the works of Jeon et al. [9][10]. Based on a surface–protein interaction model these authors demonstrated that the surface density of

Characterization of protein adsorption onto FePt nanoparticles using dual-focus fluorescence correlation spectroscopy

• Pauline Maffre,
• Karin Nienhaus,
• Faheem Amin,
• Wolfgang J. Parak and
• G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2011, 2, 374–383, doi:10.3762/bjnano.2.43

• the NP–protein interaction. The Hill coefficient, n, controls the steepness of the curve; it contains information about the cooperativity of binding. The lines in Figure 2 represent fits of Equations 3 and 5 to the data. Because all the FePt NPs were from the same batch, their hydrodynamic radius, RH